[Evaluation of human iPS cells by neural differentiation and tumorigenicity].
نویسندگان
چکیده
Evaluation of human iPS cells by neural differentiation and tumorigenicity Yohei Okada, M.D., Ph.D.and Hideyuki Okano, M.D., Ph.D. Kanrinmaru Project, School of Medicine, Keio University Department of Physiology, School of Medicine, Keio University (Clin Neurol 2011;51:1079-1080)
منابع مشابه
The Proliferation Study of hiPS Cell-Derived Neuronal Progenitors on Poly-Caprolactone Scaffold
Introduction: The native inability of nervous system to regenerate, encourage researchers to consider neural tissue engineering as a potential treatment for spinal cord injuries. Considering the suitable characteristics of induced pluripotent stem cells (iPSCs) for tissue regeneration applications, in this study we investigated the adhesion, viability and proliferation of neural progenitors (de...
متن کاملEvaluation of Neurogenic Potential of Human Umbilical Cord Mesenchymal Cells a Time- and Concentration- Dependent Manner
Background: Retinoic acid as one of the most important regulators for cell differentiation was examined in this study for differentiation of human umbilical mesenchymal cells (hUCM). Methods: After isolation, hUCM were evaluated for mesenchymal stem cell properties by flow cytometry and alkaline phosphatase assay. Also, doubling time of the cells and their differentiation potential into adipoge...
متن کاملA New Two Step Induction Protocol for Neural Differentiation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells
Background: In this study, we examined a new two step induction protocol for improving the differentiation of human umbilical cord blood-derived mesenchymal stem cells into neural progenitor cells. Materials and Methods: Human umbilical cord blood-derived mesenchymal stem cells were first cultured in Dulbecco’s modified eagle medium supplemented with 10% fetal bovine serum in a humidified incu...
متن کاملRapid Induction of Neural Differentiation in Human Umbilical Cord Matrix Mesenchymal Stem Cells by cAMP-elevating Agents
Human umbilical cord matrix (hUCM) is considered as a promising source of mesenchymal stem cells (MSCs) due to several advantages over other tissues. The potential of neural differentiation of hUCM-MSCs is of great interest in the context of treating neurodegenerative diseases. In recent years, considerable efforts have been made to establish in vitro conditions for improving the different...
متن کاملStrategies toward CNS-regeneration using induced pluripotent stem cells.
Induced pluripotent stem (iPS) cells are pluripotent stem cells directly reprogrammed from cultured mouse fibroblast by introducing Oct3/4, Sox2, c-Myc, and Klf4. Cells obtained using this technology, which allows the ethical issues and immunological rejection associated with embryonic stem (ES) cells to be avoided, might be a clinically useful source for cell replacement therapics. Here we dem...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Rinsho shinkeigaku = Clinical neurology
دوره 51 11 شماره
صفحات -
تاریخ انتشار 2011